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This List of Medications Lead to Brain Shrinkage, Dementia

5.1KViews Modified: Feb 4, 2026 · Published: Oct 23, 2025
By Jacqueline 6 Comments

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This List of Medications Lead to Brain Shrinkage, Dementia

If you’re taking medications for allergies, insomnia, anxiety, Parkinson’s, depression, or even your bladder, then you have to be careful as some of those drugs are associated with quietly increasing your risk of dementia. In fact, taking one of these very common pills, daily for 12 months, raises your risk of dementia by 50%.

In this video, we’ll be NAMING these drugs and discuss safer alternatives to discuss with your doctor. The comprehensive list is below the video.

An excellent 8 minutes by a U.S. doctor. There’s a reason this new video has been watched over 3M times.

What Are Anticholinergic Drugs?

Acetylcholine is a neurotransmitter that plays a crucial role in transmitting signals in the brain and the whole nervous systems. It directs various vital functions, including muscle movement, memory, and attention. Anticholinergic drugs block this neurotransmitter at any age.

Anticholinergic Drugs and Seniors

Especially after 65, you have fewer brain cells that can absorb acetylcholine. Thus, if you decrease the amount of acetylcholine because it’s blocked by these medications, it accelerates this downward spiral, so you have even less of this neurotransmitter circulating.

All medications –– whether prescription or over the counter –– are cleared from the body by the liver or kidneys. As you age, your liver and kidneys work more slowly, and there can be an unintentional buildup of these drugs in your system. (Always check with your doctor to make sure you are on the right dose of a medication for your age.) As such, you can have severe side-effects from these anticholinergic drugs.

Even when used as instructed, anticholinergics can have a number of unpleasant side-effects. Of course, these will vary depending on the specific drug and dosage.

The side effects include:

• blurry vision

• constipation

• drowsiness

• sedation

• trouble urinating

• memory issues

• hallucinations

Another side-effect is that these drugs can decrease sweat production and thereby raise your body temperature. This can lead to heatstroke.

A Comprehensive List of Anticholinergic Drugs

This comprehensive list is courtesy of The People’s Pharmacy and was included in Dr. Shelly Gray’s study1 at the University of Washington:

• Amitriptyline (Elavil)

• Atropine

• Benztropine (Cogentin)

• Chlorpheniramine (Actifed, Allergy & Congestion Relief, Chlor-Trimeton, Codeprex, Efidac-24 Chlorpheniramine, etc.)

• Chlorpromazine (Thorazine)

• Clomipramine (Anafranil)

• Clozapine (Clozaril)

• Cyclobenzaprine (Amrix, Fexmid, Flexeril)

• Cyproheptadine (Periactin)

• Desipramine (Norpramin)

• Dexchlorpheniramine

• Dicyclomine (Bentyl)

• Diphenhydramine (Advil PM, Aleve PM, Bayer PM, Benadryl, Excedrin PM, Nytol, Simply Sleep, Sominex, Tylenol PM, Unisom, etc.)

• Doxepin (Adapin, Silenor, Sinequan)

• Fesoterodine (Toviaz)

• Hydroxyzine (Atarax, Vistaril)

• Hyoscyamine (Anaspaz, Levbid, Levsin, Levsinex, NuLev)

• Imipramine (Tofranil)

• Meclizine (Antivert, Bonine)

• Nortriptyline (Pamelor)

• Olanzapine (Zyprexa)

• Orphenadrine (Norflex)

• Oxybutynin (Ditropan, Oxytrol)

• Paroxetine (Brisdelle, Paxil)

• Perphenazine (Trilafon)

• Prochlorperazine (Compazine)

• Promethazine (Phenergan)

• Protriptyline (Vivactil)

• Pseudoephedrine HCl/Triprolidine HCl (Aprodine)

• Scopolamine (Transderm Scop)

• Thioridazine (Mellaril)

• Tolterodine (Detrol)

• Trifluoperazine (Stelazine)

• Trimipramine (Surmontil)

Other Anticholinergic Drugs (with Lesser Anticholinergic Effect)

Here are some other anticholinergic drugs to watch out for. Generally, they have a weaker anticholinergic effect. Still, you should be mindful of using these drugs, especially if you are already taking another anticholinergic; combining them can result in serious injury or even death:

• Alprazolam (Xanax)

• Amantadine (Symmetrel)

• Baclofen

• Carisoprodol (Soma)

• Cetirizine (Zyrtec)

• Cimetidine (Tagamet)

• Clorazepate (Tranxene)

• Codeine

• Colchicine

• Digoxin (Lanoxicaps, Lanoxin)

• Diphenoxylate (Lomotil)

• Fluphenazine (Prolixin)

• Furosemide (Lasix)

• Hydrochlorothiazide (Esidrix, Dyazide, HydroDIURIL, & Maxzide)

• Loperamide (Imodium)

• Loratadine (Alavert, Claritin)

• Maprotiline

• Nifedipine (Adalat, Procardia)

• Ranitidine (Zantac)

• Thiothixene (Navane)

• Tizanidine (Zanaflex)

A report published in JAMA Internal Medicine showed compelling evidence of a link between use of anticholinergic medications (like the pharmaceuticals and OTC meds above) and dementia.

Study results: Taking these drugs for the equivalent of three years or more had a 54% higher dementia risk than taking the same dose for three months or less. (source)

It’s Really Time to Stop

1  minute.

There is evidence we can bring even aging people back with intentional care IF this behavior is STOPPED!

One retired hospice nurse wrote. “Our patients were taken off their regular medications and put on comfort meds only. A few dementia patients had so many medications that it took 2 or 3 pages of paper to list them all. They were a few patients who were just a few days from death and when they were taken off all their medications, improved so much that we discharged them because they were no longer dying.”

My own awesome husband took his dad, still in his own home with round the clock care and in his early 90s, off 14 medications because he became totally confused. He drooled, needed a diaper, and slept all day. After a few weeks, he started to perk up and once again enjoyed his food and conversation. Within 5 months, he was back to playing a mean game of euchre with his old buddies and lived a great life for 2 more years. I watched this first hand and know others who have done the same thing with their loved ones. ~Jacqueline

Another wrote, “My grandmother had in treated sleep apnea, but also took Benadryl EVERY SINGLE DAY. For over 10 years. She eventually began have psychotic episodes and they diagnosed her with dementia with psychosis. We moved her out of her moldy dusty apartment, got her her cpap machine, put her on a ketogenic diet. Forbid her from ever taking Benadryl ever again. Besides her memory being slightly off, she lives on her own now and has done a completely 180! Happy, healthy, loving life in sunny San Diego!” 

So don’t give up! Fight back and take your life or that of your loved one back.

“As iron sharpens iron, so one person sharpens another.” ~Proverbs 27:17

****For the Full Spike Protein Protocol to protect from transmission from the “V” and to help those who took the “V”, go here.

***If you found value in this writing, please share it, discuss it, and subscribe to my FREE newsletter. Independent, ad-free work like this spreads because of readers like you.

Also, please consider supporting my work by using my Amazon affiliate link when purchasing from there.

printable or PDF

Censorship is real. My Pinterest account was suspended; HOWEVER, part of my main board is still alive through this link, and it scrolls down a long way!

You can also find me on Facebook, Gab, MeWe, X (Twitter), and Instagram.

Medical Disclaimer: I am no longer a practicing medical professional, and I am not doctor. I am a mother. I do seek scientific confirmation of the safety and effectiveness of the herbs and remedies I use. Using remedies is a personal decision. Nothing I say on this blog is intended to treat or prevent disease. Consult your own doctor.

©2026 Deep Roots at Home • All Rights Reserved

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Hi! I’m Jacqueline!

Thanks for being part of this journey with me.
Welcome to my own little place on the internet! Home is where I love to be. I feel there is no greater place to incubate souls. These days you’ll find me using my experiences here to write about herbal remedies and natural health research — a big passion of mine. But being a wife and mother is not easy. It is challenging and potentially lonely. I get that. I wanted to create a place to connect with and support other moms for creating a natural, healthy, and fulfilling home life.
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Reader Interactions

Comments

  1. Ester

    October 25, 2025 at 12:49 pm

    Thank you for publishing this important information!!!
    Just wanted you to know I clicked over the your Amazon link and it opens the app but not your link, I would love to support you if possible and purchase from there.
    Keep up- your work means so much to me.

    Reply
    • Jacqueline

      October 25, 2025 at 3:16 pm

      Hi, Ester, thank you for being so conscientious and checking the link to make sure it is a good one.
      I asked my daughter who is here visiting if it was the right link, and she said it is good on her end. So maybe try again and place an little order (if you are ready to place one) and see what happens. I wish I knew how to help you, and I thank you so, so much for your kindness and support.
      God bless you,
      Jacqueline

      Reply
  2. C Thompson

    November 07, 2025 at 11:32 am

    What is the best medication for allergies? I see Zyrtec and chlorpheniramine on this list, which I take for allergies.

    Reply
    • Jacqueline

      November 09, 2025 at 4:22 pm

      C. Thompson, see my response to Kay in this thread of comments. Homeopathics are wonderful and all I use bc they work with zero side effects!!
      Blessings,
      Jacqueline

      Reply
  3. Kay

    November 07, 2025 at 4:06 pm

    Thank you! Thank you! Thank you!! My husband has been on Loratadine for years and I have been for a lesser amount but was put on Benedryl recently. I wondered why at 65 his mind was slipping a bit. Stopping immediately!! We’ll deal with the allergies.

    Reply
    • Jacqueline

      November 09, 2025 at 4:20 pm

      Kay, praise God that you are stopping! I use homeopathy and it works SO WELL! I use these 2 together:
      Allergy combo: https://www.elixirs.com/products.cfm?productcode=HH18B and
      https://www.elixirs.com/products.cfm?productcode=S94VV
      If your nose or sinuses are involved, add this (all 3 can be taken together): https://www.elixirs.com/products.cfm?productcode=HH23
      I think that will bring you relief.. take 15 minutes away from food, toothpaste, and drink other than water so the remedies aren’t neutralized.
      Let me know if that works for you!
      ~Jacqueline

      Reply

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