This is a very personal post for me. Grapefruit Seed Extract (GSE) was just one part of a protocol to treat and ultimately heal our 4 year-old son after a simultaneous Stachybotris mold and Klebsiella exposure that could have taken his life if we didn’t piece together what happened! You can read his story here.
We have used grapefruit seed extract since 1997. Providentially, I learned about it from our integrative medicine doctor right when we needed it most! This is one of those very helpful more-natural products you will not be hearing much about, sadly.
Broad Spectrum Antimicrobial
Used as a broad-spectrum, non-toxic, antimicrobial product, Grapefruit seed extract is known to be highly effective for fighting infection. GSE is used as a purifier, antiseptic, and preservative. Scientific research shows that pure, grapefruit seed extract is
It fights:
• candida
• kills antibiotic-resistant UTIs
• against MRSA (methicillin-resistant Staphylococcus aureus)
• and digestive trouble associated with eczema
You can see some of the many scholarly articles on grapefruit seed extract here for specific uses, I have linked many more below if you are interested.
Good vs. Bad Bacteria
GSE is highly effective at rebalancing and differentiating between the “good” microflora (bacteria) and the bad. By destroying the bad bacteria, fungus, and pathogens, the good bacteria has a stronger opportunity to do its work and keep you healthy. (source)
Your body will also have a much stronger resistance to stomach bugs and intestinal ailments.
Who Should Not Take Grapefruit Seed Extract?
Grapefruit seed extract is non-toxic and considered safe in most cases. An independent laboratory found that you would need to take 4,000 times the recommended amount of grapefruit seed extract before the dosage became poisonous.
However, as with any form of supplementation, GSE is not recommended for women who are pregnant or breastfeeding. Those with serious health conditions are also advised to seek advice from a health professional before commencing GSE treatment. It is possible for GSE to interact with certain medications, so these should be checked first.
Side-effects of GSE are rare. One solid study reported patients suffered no side-effects during a four-week treatment with GSE. Instead, they noticed an overall improvement in digestive health symptoms, including constipation, flatulence, abdominal discomfort and night rest.
Remember that grapefruit seed extract is known to have a large number of drug interactions. In many cases, GSE substantially reduces the effectiveness of prescription medication. If you are taking any medication, make sure to check with your healthcare provider.
Common sense: Never put the extract into your eyes, and don’t use at full strength in your mouth, ears, nose or sensitive areas. If used in full strength on skin it may cause irritation.
Know Your Source
Always buy from a reputable company (we keep Nutribiotic GSE on hand -see customer Q&As about purity). Beware of some commercial brands are not pure and contain benzethonium chloride and triclosan. Dr. Axe mentions this one.
Grapefruit Seed Extract Dosage:
University Health News Daily and Dr. Axe recommend:
• Adults can take one to two 250 mg capsules or tablets 2-3 times daily with or without meals. GSE liquid is extremely bitter.
• Or adults can mix 5-10 drops of the liquid concentrate into a glass of water (5-6 oz.) OR add to empty capsule and take immediately, 1-3 times daily, with or without meals.
• Grapefruit extract can deplete normal flora (‘good’ bacteria) in the gut when taken very long-term. If taking GSE for 3-4 days or longer, it’s important to consume a probiotic supplement two hours before taking your GSE dose. Use a good probiotic thru-out.
• Grapefruit seed extract concentrated liquid and capsules should not be taken by children except under a doctor’s supervision. Seek out a functional medicine doc.
• If you have candida, it’s best to begin GSE therapy in partnership with a cleansing anti-candida diet. This means avoiding things like sugar, alcohol, dairy and grains.
• For more dosages for sinus, earaches, sore throat, colds, viruses, gingivitis, and candida, Applied Health has helpful directions.
For breastfeeding mothers with thrush and candida:
According to the Canadian Breastfeeding Association grapefruit seed extract can be used directly (diluted) on affected nipples. It should be diluted (5 to 15 drops, occasionally up to 25 drops, in 1 ounce water), applied on the nipples with cotton ball, allowed to dry, and then covered, sparingly, with ointment. Cover the dilute GSE for more uses. Use it only after nursing.
It may be helpful to treat baby with acidophilus by rolling a wet finger in acidophilus powder (break open a capsule), and let baby suck on the finger right before a feeding. Use 2x first day, 2x second day only. Mother may want to ingest Acidophilus as well, 3x/day for 1-2 weeks. (source)
Other Neat Antimicrobial Uses for Grapefruit Seed Extract:
(Source)
• In humidifiers – 3-4 drops per gallon of water to prevent algae growth
• In nebulizers – one drop GSE to one ounce saline water for control of respiratory infections
• In laundry – to kill fungi and bacteria, add 10-15 drops to the final rinse
• Disinfecting surfaces (cutting boards, bathroom surfaces) – 15-20 drops mixed in 32 oz.water in a spray bottle
• Farming – in chicken feed and water to reduce the incidence of infectious diseases
Note: I did my research. We had such good success with GSE (as many doctors have). We would rather have our son get well than fear some of the biased criticism out there. See my medical disclaimer and consult a functional doctor (Dr. Axe’s list) who is up to date with safer, non-pharmaceutical alternatives.
How Is He Now?
The Outcome
Today, our son is a strapping, healthy young organic farmer, still prone to candida and sinus infection if he doesn’t watch his sugar intake. He started to grow again after 6-7 years and made up for lost time by growing taller than his mama! Grapefruit seed extract was part of what helped to save his life.
More of the story and what else we did.
One day, maybe I’ll share the 8-day rotation I came up with and kept him on for 3 1/2 years!
And though this world, with devils filled,
Should threaten to undo us,
We will not fear, for God hath willed
His truth to triumph through us.
The Prince of Darkness grim,
We tremble not for him;
His rage we can endure,
For Lo! his doom is sure;
One little word shall fell him.
~Martin Luther: “A Mighty Fortress is Our God”
***For the Full Spike Protein Protocol to protect from transmission from the “V” and to help those who took the “V”, go here.
***If you found value in this writing, please share it, discuss it, and subscribe to my FREE newsletter. Independent, ad-free work like this spreads because of readers like you.
Also, please consider supporting my work by using my Amazon affiliate link when purchasing from there.
Censorship is real, so my Pinterest account was suspended; thankfully, a big part of my main board is still alive through this link!
You can also find me on Facebook, Gab, MeWe, X (Twitter), and Instagram.
©2026 Deep Roots at Home • All Rights Reserved
Joanna
YES! Thank you for this!
After being unable to nurse our oldest, I got thrush with our 2nd for 4 months. Nothing else worked- I tried all the “normal” medications, but apparently it was a resistant strain. GSE finally got rid of the thrush, but then I read some very critical reviews of it, so my DH suggested we not use it anymore.
I’ll definitely be mentioning this article to him. ☺
Shelley Brown
I’ve learned so many things nutrition and health-wise from your site! I looked but couldn’t find any posts where you recommend books that you may have learned from. Could you recommend books for learning more about natural healing & healthy living. Or even websites that you follow to get information? Also, I live more than 1 1/2 hrs from the nearest naturopath, functional doctor or osteopath doctor. Do you recommend seeing a regular MD in this case and just using what I learn from sites like this and books I read to take care of my body?
Jacqueline
Hi, Shelley!
Thank you for your kind words. I think the Lord just took me/us on some difficult things healthy-wise (with infertility, being allergic to all antibiotics, mold issues after our children came, and subsequent years of quashed immune systems and leaky gut/behavioral, etc.) and so I had to re-evaluate everything I learned in nursing school and start to research for myself. I’ve had 45 years of counseling moms on the phone with sick kids and special needs work in my spare time. The Lord has just used it all to give a well-rounded background. Maybe I should write a post on the books, too, to numerous to mention and some very old (like peds doc Dr. Lendon Smith)! There are some great sites like Mercola (which I generally trust), Chris Beat Cancer, https://www.naturalnews.com/ and researchers I love to listen to like Suzanne Humphries and pediatrician Dr. Paul Thomas of Portland on Youtube.
Lastly, I love to read studies on PubMed to verify things I think are true, but need more info.
Also, I always ask the Lord for wisdom now and it makes all the difference! I hope this helps!
Blessings! J
Leanne
I was so happy to find this page. My daughter has the bacteria klebsiella and struggling to heal . Could you please tell me the dosage and protocol you used with the grapeseed oil ? Thank you kindly ?
Jacqueline
Leanne, the dosage and tips are all in the post in the lower half! I think you find it helpful! ~J
Laura
Please share the 8 day rotation you kept him on for 3 1/2 years. My son had black mold exposure, he’s almost 3. Please share?