Can Ivermectin Play a Role In Treating Neurological Diseases? Yes

I must begin with a cool bit of history of the near-miraculous discovery of Ivermectin, then we will get to what it can do for Parkinson’s, dementia and possibly MS and ALS and other neurological concerns:

The Fascinating Discovery & Development of Ivermectin

Most drug-discovery stories are stories about designing a molecule. This one is about Satoshi Ōmura finding one — in a sample of bacterium, in a spoonful of soil, near a golf course on the Japanese coast. It runs from a handshake between a Tokyo institute and Merck, Sharp, and Dohme research lab where William Campbell led a team in studying Ōmura’s cultures and identified a successful treatment they named Ivermectin (generic) or Mectizan®. In 1987, (back when profits were not as important as helping others), Merck decided to donate Ivermectin (Mectizan®) free of charge, providing it to around 300 million people, in a total of 33 countries, every year since. (source). It became a human medicine on the World Health Organization’s essential-medicines list, and Ōmura and Campbell shared the 2015 Nobel Prize.(source)

“I did half the work for the Nobel Prize, but the credit for the other half goes to the microbes,” said Professor Satoshi Ōmura, distinguished professor emeritus at Kitasato University. The soil culture was named Streptomyces avermitilis and became this novel therapy (Ivermectin) against parasitic infections (and apparently neurological diseases – as you’ll see below). Over decades of searching, the organism has never been found anywhere else on earth. Many consider this a near miraculous chain of events.

What Can Ivermectin Do For Neurological Diseases (Parkinson’s, dementia, etc.):

The Journal of Antibiotics’ landmark study “Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations” published in Nature (2017) opened the eyes of millions to the miracle of Ivermectin. Ivermectin saved hundreds of thousands of lives during Covid by keeping them out of the deadly hospital environment.

For neurological diseases, Ivermectin exerts much of its neuroprotective effects by modulating P2X4 (Nature, 2017). “Because of its action on P2X4 receptors, ivermectin has potential for all motor neuron diseases.”

(As an aside, Ivermectin reverses the effect of alcohol on P2X4 and has the potential to reduce cravings and consumption of alcoholic beverages in those afflicted with substance use disorder.)

However, back to neuroprotection.

If it is neuroprotective, and the evidence is growing that it is, and humanity is being bombarded with various neurotoxins and electromagnetic frequencies each day that compromise our nervous system, perhaps there is reason to consider Ivermectin as a neuroprotective repurposed drug worthy of use during this dangerous time in our history. Ivermectin’s main mechanism of action in neuroprotection seems to be its stabilization of P2X4 receptors (Neuroscience Bulletin 2020).

Can Ivermectin play a key role in treating Neurological Disease?

Three more recent peer-reviewed papers (below) suggest it might.

1. Anti-Inflammatory Effects

A 2023 study published in Inflammation demonstrated that ivermectin mitigates neuro-inflammatory damage in a mouse model of experimental autoimmune encephalomyelitis. The compound reduced pro-inflammatory cytokines such as IL-17A and IFN-γ and promoted regulatory T-cell activity (Springer, 2023). These mechanisms are relevant to Alzheimer’s disease, where microglial activation and cytokine dysregulation contribute to neuronal degeneration.

2. Synaptic Modulation and Inhibitory Neurotransmission

Ivermectin potentiates glutamate-gated chloride channels (GluClRs), enhancing inhibitory postsynaptic currents. A 2019 study in PLOS Pathogens found that ivermectin increased tonic inhibitory currents and prolonged synaptic inhibition, possibly restoring balance in neural circuits disrupted by neurodegeneration (PMC6368337).

3. Cholinergic Enhancement and Dopaminergic Crosstalk

A 2024 study published in Cell & Bioscience reported that ivermectin increased activity of striatal cholinergic interneurons, thereby enhancing dopamine release via nicotinic receptor modulation (PMC11025261). Since cholinergic deficits underlie many cognitive symptoms in Alzheimer’s, Ivermectin’s indirect cholinergic enhancement may complement standard therapies.

Ivermectin and Parkinson’s Disease: 3 Case Reports

Case No. 1

Dr William Makis shared 1 case testimonial of ivermectin and Parkinson’s disease on X.com (August 2025): IVERMECTIN and FENBENDAZOLE Testimonial – 78 year old Nebraska PARKINSON’S DISEASE patient of 8 years, cured after 4 months!

“We started in March, 2025, Ivermectin 1mg/kg/day increasing to 1.5mg/kg/day and Fenbendazole 888mg/day. From patient’s daughter: “He has been on the protocol you gave him for four months. Today he went to the neurologist…and unbelievably the doctor told my dad that he is now questioning if my dad even has Parkinson’s anymore…he told my dad he looks healthier than he’s ever looked!” He doesn’t shuffle or slump over like he used to and his shakes are minimal!!! My dad was just speechless!”.

Case No. 2

@Eileen_Graf5689 shared on X.com (August 2025): “I was an RN (now retired). After the Covid jab and then coming down with Covid, my mom has symptoms of Parkinson’s (pill rolling, shuffling gait, flat affect, irritability, most of the time she was nonverbal, fatigue, stiffness). I gave her ivermectin 15 mg 2x a day. Cured after 4 weeks.“

Case No. 3 (Oct 2024)

Dr. Makis published this case of substantial improvement with the use of Ivermectin. The patient wrote: “I would like to set up another meeting as soon as it is convenient for you. I did see some improvements with the Ivermectin, freedom of upper body movement, normalized bowel movements, and my expression is back to normal, not stiff and unnatural. I did, however, have an issue with my vision, which I emailed you about. I stopped the Ivermectin, and it went back to normal within 2 days. I haven’t taken it since that time, so should I restart it? FYI. I take liquid, not the pills as it is much more affordable.” (see case here),

Dr. Makis on Parkinson’s and Alzheimer’s with beginning low doses of Ivermectin. (More by Dr. Makis here, here, here, here, here, and here)

3 minutes:

Ivermectin and Dementia (6 Case Reports)

Six case series suggest ivermectin may help treat dementia. Dr. William Makis shared 6 case testimonials of ivermectin and dementia on X/Twitter (February 2025):

Case 1: Vascular Dementia: “My father has been taking Ivermectin for Vascular Dementia now for 5 days…he seems much calmer, less agitated. We have noticed significant change in my father…he seems more tranquil, less rebellious and frustrated…only 1 week on Ivermectin so far but very positive so far.”

Case 2: Alzheimer’s Dementia: “I gave my mother-in-law Ivermectin 12mg x 5 days. She is 84 and suffers with dementia. She slept almost all night those 5 nights. That is a HUGE improvement over wandering around the house all night.”

Case 3: Cognitive Decline & End of Life: “I have seen phenomenal results recently with my father’s (82yo) health specifically with his cognitive improvements but also his energy levels and his appetite. Began giving him Ivermectin and the results were fast and absolutely remarkable. His ability to speak and hold a conversation and actually be humorous with us generated a wave of emotion for our family as we went from a near death diagnosis to hospice care dropping him from their program within just a few weeks. What an incredible gift we have been given!”

Case 4: (Brazil) – Memory loss: “My father…81 years old…major loss of memory…we managed to get him to agree to use a daily dose of 24mg…we saw a little improvement, with more words in his vocabulary, a better sense of time and sense, knowing that he has a bond with us.”

Case 5: New Onset Dementia: Dr William Makis shared a case testimonial of ivermectin and dementia on X/Twitter (January 2025). This 93 year-old Grandma recovers dramatically with low dose Ivermectin:

Case 6: Dementia and End of Life: Another written by someone who had used ivermectin for their 97-year-old demented father to suppress a COVID-19 infection – and the patient begins to REMEMBER. (X/Twitter November 2024): “I gave him 24mg of Ivermectin on day 1. I continued with IVM for 4 days” …“His eyes lit up and he recognized me. Each day when I visited, he became more of the father I knew decades prior. We had wonderful conversations, his confusion was gone and he was laughing and talking”. What an incredibly touching story!

Dr. Makis writes, I am currently helping 4 Parkinson’s Disease patients with Ivermectin, two Multiple Sclerosis, one ALS (Amlotrophic Lateral Sclerosis) and one Seizure.This is in addition to hundreds of Cancer patients. But I was not aware of literature on Ivermectin and Dementia. There IS some evidence for the use of Ivermectin in Dementia, except it looks like it has been scrubbed from GOOGLE and the file is conveniently “not available”. “Ivermectin can be used as a therapeutic candidate in Alzheimer disease which will need more studies to support that.” – 2021.

Ivermectin and Fenbendazole for White Matter Disease

Rachel Coffenberry shared on X/Twitter (Dec 2024): “8 weeks of low dose Ivermectin & 5 weeks of fenbendazole, 222mg, have almost alleviated every bit of neuro/cognitive symptoms that I have suffered with for over 2 years!! They said that my Moderate/Severe White Matter Disease was mimicking a Rapid Progressive Dementia!”

An international source for Ivermectin many used successfully will be ending soon:

UPDATE: You can get Ivermectin, HCQ, and more from India via lifebeltcorporation.com. The word is that ordering will be shut down on January 20, 2027, so get orders placed asap! <<<(Many I know were using and have used this resource, NO scrip needed). Off to the right side of your screen, you should see the blue “Enquire Now” box. Click that to enter what you are interested in exactly with dosage and quantity, and “Submit”. These meds are very inexpensive, but also high quality and made in India, NOT CHINA!! (Caveat, I cannot vouch for their response or lack of it, shipping agreements or website changes/issues.)

NAC (N-Acetyl Cysteine), Glutathione, and Neurological Diseases like Parkinson’s

Some research has suggested that NAC, a precursor of glutathione production in the body, may protect the brain in people with Parkinson’s Disease. In one clinical study, it improved the activity of dopamine neurons, which are incredibly important in this disease [2016].

“Researchers have subsequently found that decreased levels of glutathione does not directly result in dopamine cell loss … but it does make the cells more vulnerable to damaging agents (such as neurotoxins …) This has led investigators to ask whether administering glutathione to people with Parkinson’s disease would slow [down] the condition.”

Studies have confirmed the usefulness of NAC. In one study (2017), 23 patients found a combination of 600 mg of oral NAC twice a day plus a weekly IV infusion of NAC at 50 mg per kilogram of body weight, had a very consistent, neuroprotective effect, improving patients’ mental and physical abilities. (Even without the IV, oral dosing would be helpful. During Covid, many of us took NAC 1800-2400 mg, split/day).

“And God is able to bless you abundantly, so that in all things at all times, having all that you need, you will abound in every good work.” ~2 Corinthians 9:8

****For the Full Spike Protein Protocol to protect from transmission from the “V” and to help those who took the “V”, go here.

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Medical Disclaimer: I am no longer a practicing medical professional, and I am not doctor. I am a mother. I do seek scientific confirmation of the safety and effectiveness of the herbs and remedies I use. Using remedies is a personal decision. Nothing I say on this blog is intended to treat or prevent disease. Consult your own doctor.