Melatonin has many important functions besides natural sleep regulation.
Melatonin recharges glutathione; it has anticonvulsant and antiexcitotoxic properties, and is a potent antioxidant with the rare ability to enter your mitochondria.
Notably, it plays an important role in cancer prevention and may prevent or improve certain autoimmune diseases, such as Type 1 diabetes.
In viral infections, melatonin raises the host’s tolerance to the virus.
This gives the host time to develop the adaptive immune response and eradicate the invading pathogen.
Melatonin Has Important Role in COVID-19 Treatment
Over the past two years, melatonin has emerged as a surprise weapon against COVID-19.
As early as June 2020, researchers suggested it might be an important adjunct to COVID-19 treatment. According to the authors of that paper, melatonin lessens several pathological features of COVID-19, including:
- Excessive oxidative stress and inflammation
- Exaggerated immune response resulting in a cytokine storm
- Acute lung injury
- Acute respiratory distress syndrome
In October 2020, another scientific review summarized how melatonin can also protect against and also lessen viral infections such as:
- respiratory syncytial virus (RSV)
- viral hepatitis
- viral myocarditis
- Ebola, West Nile, and dengue virus
Melatonin Lowers COVID-19 Mortality
A large study by Hasan et. al. found melatonin significantly lowered mortality when given to severely infected COVID patients.
In the standard care only group, 13 of the 76 patients died (17.1%), compared to just one of the 82 patients (1.2%) who received melatonin in addition to everything else. That’s a reduction in mortality of 93%, which is quite remarkable.
All of the patients given melatonin improved within four to five days, and all survived. On average, those given melatonin were discharged from the hospital after 7.3 days, compared to 13 days for those who did not get melatonin.
The study used 10 mg melatonin (Natrol® brand). (source)
According to Mercola’s article, the authors stated that ‘at under $5 per course of treatment, melatonin is a cost-effective addition to any treatment plan’. (You would not need even a full bottle of melatonin) For comparison, Regeneron monoclonal antibodies cost about $2,100 per dose and remdesivir is $3,100 per treatment.
Melatonin Is an Integral Part of Front Line Protocol
Early in 2020, the Front Line COVID-19 Critical Care Alliance (FLCCC) developed preventive, outpatient treatment and inpatient protocols based on the insights of the founding critical care doctors. Dr. Paul Marik, a critical care doctor known for his life-saving vitamin C sepsis protocol, is one of those doctors.
Marik’s paper in the Journal of Thoracic Disease gives the scientific rationale for using it in sepsis.
The FLCCC has included melatonin in its early treatment and hospital treatment protocols from the start. You can download the latest protocols on the FLCCC’s website.
Recommended Dosage:
As a supportive therapy, the FLCCC recommends taking 6 mg of melatonin before bed if you’re treating early or mild symptomatic COVID-19. The hospital treatment protocol calls for anywhere from 6 mg to 12 mg of melatonin at night, until discharge.
For patients treating long-haul COVID-19 syndrome (LHCS), they recommend taking between 2 mg and 12 mg nightly. Begin with a low dose and work your way up as tolerated. If your sleep is disturbed, lower your dose. (Low doses of melatonin will help make you sleepy, while higher doses can trigger sleeplessness.)
General Guidance for Supplementation by Dr. Mercola:
It would be prudent to only use doses this high for limited times when you might need them.
While the doses suggested (when used against COVID) are higher than what you’d normally take to improve your sleep, there does not appear to be any danger to these doses.
I recommend starting low, at 1 mg or less — be sure to take melatonin at night, before bed. Rising melatonin levels is the reason you feel sleepy in the evening, so it’s ill advised to take it in the morning or during the day, when your natural level is (and should be) low.
It is also best taken as a sublingual tablet. Sublingually, it can enter your blood stream directly and doesn’t have to go through the digestive tract. As a result, its effect will be felt more rapidly.
Research has found no adverse effects for dosages ranging from 20 mg up to 100 mg. (source)
Melatonin is not for children, and they seldom get covid. They have naturally high levels already.
[Excerpts from Dr. Joseph Mercola’s article Jan. 13, 2022]
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