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Naturally Shut Off 4 Chronic & Autoimmune Inflammation Pathways

2.8KViews Published: Feb 12, 2026
By Jacqueline 4 Comments

Naturally Shut Off 4 Chronic & Autoimmune Inflammation Pathways
(Image from the video below)

Learn the best food and herbal home remedies for pain and inflammation, and discover how to address the 4 inflammation pathways at their root.

Inflammation is a fundamental biological process essential for defending the body against pathogens, toxins, and cellular damage. Tissue inflammation is a dynamic process that develops step by step, in response to an injury, to preserve tissue integrity. Local cells are involved first, and once activated, they produce pro-inflammatory mediators and cytokines that, in turn, activate downstream pro-inflammatory signals. (source)

Fever, for example, is how you know your body’s inflammatory system is working correctly when you’re ill. But inflammation can harm you if it occurs in healthy tissues or goes on for too long. (source)

Dr. Berg’s 10 minutes video sums up several practical approaches to halt it.

At 8:45, he he mentions he has seen people with even the most severe autoimmune inflammatory conditions completely get rid of inflammation by adding one specific strategy. Also covered are 4 basic herbs that need to be included in treatment.

There are 4 biochemical pathways that act as “master switches” to turn pain and inflammation up or down:

1. The pain and inflammatory factory (COX)

2. The master inflammation on-switch (NF-kB)

3. The inflammation megaphone (TNF-∝)

4. The backup inflammatory alarm system (5 LOX)

What turned on the inflammation in the first place?

There are 5 primary causes that flip the inflammatory switches on, leading to pain and inflammation in the body. (By addressing the root cause, you can correct the pain rather than simply managing it.) The following 5 factors turn on all of the inflammatory switches:

• Insulin resistance

• Mitochondrial damage

• Chronic oxidative stress

• Leaky gut

• Chronic infections

Many anti-inflammatory treatments do not address all 4 pathways.

Ibuprofen is great at turning the pain and inflammation pathway switch off, and does so very quickly. Unfortunately, ibuprofen can also cause stomach ulcers and kidney issues, because the pain and inflammation pathway protects the stomach and kidneys. It also doesn’t address the other 3 inflammatory pathways, which is why people often have to take it repeatedly.

Tylenol works in the brain, affecting the central nervous system, but does not relieve any inflammation.

Similar to ibuprofen, aspirin works on the first inflammatory pathway, which can also affect your stomach.

4 Natural Supplements That Address All 4 Pathways

• Turmeric affects 3 out of the 4 inflammatory pathways! 

A double-blind randomized controlled study found that taking 1500 mg of turmeric with black pepper produced results comparable to ibuprofen without the side effects. 

According to the traditional medical community, 3,000 mg. is the maximum amount of standardized turmeric curcumin you should take per day, yet multiple studies used up to 8,000 mg with NO toxicity. Cancer would be one situation where more is used successfully. (source)

While turmeric spice typically contains between 2% to 9% curcumin, supplements may contain up to 95% curcumin. (source) And added black pepper is a natural piperine that enhances curcumin absorption. Incorporating turmeric into a meal with fats can increase the absorption of curcumin by the gastrointestinal tract.

One teaspoon of this turmeric golden paste recipe is equal to ~2,000 mg. You can also add golden paste to a variety of foods and beverages. For example:

  • coffee or tea
  • soups and broths
  • roasted vegetables
  • rice dishes
  • lentil or bean stews

Best to take smaller quantities 3-4 times per day, especially if battling chronic neuro-degenerative, cardiovascular, pulmonary, metabolic, autoimmune diseases, or cancer. When cooking with turmeric powder, East Indian cultures routinely use up to 3 grams (3,000 mg.) per day. However, turmeric can cause abdominal upset in some when taken in high doses, so it needs to be divided through the day. (source)

I purchase this very popular brand to have capsules on hand, and my husband takes 3-4/day (split up) of this nano-particle sized product that includes curcumin, boswellia, quercetin, berberine, and more.

Turmeric does NOT harm the liver. 

• Extra-virgin olive oil mimics ibuprofen’s effects at the molecular level due to the monounsaturated fats content and to the presence of phenolic compounds that have antioxidant, anti-inflammatory and immunomodulatory properties. Try adding it to your salad regularly.

• Ginger is anti-inflammatory due to compounds which can help reduce pain and inflammation in conditions such as arthritis and muscle soreness. It may also aid in managing inflammation related to autoimmune diseases. (source)

• Foods rich in omega-3 fatty acids increase the levels of omega-3s in your cell membranes and give protection against several diseases that are associated with uncontrolled inflammation. (source)

Food rich in omega-3 includes fish such as salmon, sardines and mackerel, seaweed, walnuts, eggs, avocados, flax seeds and unadulterated pure extra-virgin olive oil. (Image source)

• Boswellia targets the 5-LOX pathway, also known as the backup inflammatory alarm system,

Related:

Turmeric: Evidence No-Side-Effect Power Beats Prozac, Ibuprofen & More

Inflammation Bomb: Tomato-Turmeric Pepper Soup Family Recipe

Alzheimer’s Recoveries Reported After Administration of Turmeric

How To Make (& Use) Highly Bioavailable Turmeric Golden Paste

“Bless the Lord, O my soul, and forget not all his benefits…” ~Psalm 103: 2

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Medical Disclaimer: I am no longer a practicing medical professional, and I am not doctor. I am a mother. I do seek scientific confirmation of the safety and effectiveness of the herbs and remedies I use. Using remedies is a personal decision. Nothing I say on this blog is intended to treat or prevent disease. Consult your own doctor.

 

©2026 Deep Roots at Home • All Rights Reserved

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Hi! I’m Jacqueline!

Thanks for being part of this journey with me.
Welcome to my own little place on the internet! Home is where I love to be. I feel there is no greater place to incubate souls. These days you’ll find me using my experiences here to write about herbal remedies and natural health research — a big passion of mine. But being a wife and mother is not easy. It is challenging and potentially lonely. I get that. I wanted to create a place to connect with and support other moms for creating a natural, healthy, and fulfilling home life.
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Reader Interactions

Comments

  1. Carol

    February 12, 2026 at 5:17 pm

    Can you take the Tumeric when on a blood thinner- that’s an issue with chronic pain – what options that work are there that won’t be contraindicated??

    Reply
    • Jacqueline

      February 12, 2026 at 6:31 pm

      Hi, Carol,
      Everyone agrees that amounts normal in spice-seasoned food are not contraindicated, but to be wise and proactive as a patient, start slowly and low and watch for any bruising and let that be your guide..
      You can add golden paste to a variety of foods and beverages (in low ‘food amounts’) as listed in the post. Also, he doesn’t even give it a mention in the video so ‘food amounts’ aren’t a big no-no. One (level) teaspoon of turmeric golden paste recipe is equal to ~2,000 mg, so I’d start with 1/4 -1/2 tsp (~500-1000 mg) and work with that. Any low amounts (split) you can get in w/o bruising should help your pain to some degree. I hope that helps! ~J

      Reply
  2. Judi Morris

    February 17, 2026 at 11:40 am

    I’m excited to try some of the things you mentioned in this article! I have fibromyalgia and a body that is in awful pain every day. This article will be read several times so that I can really absorb it all! I’ve followed you for years now and love what you do! Thank you, Jacqueline!

    Reply
    • Jacqueline

      February 17, 2026 at 1:52 pm

      Judi, I do hope you will find some relief for your fibro. That is so hard!
      Have you tried TRS for the inflammation? I have worked with a number of people that have reported written details for me of how it has helped them but getting to the root cause and radically lowered their toxic load. I can send some to you in an email if you want me to since I can’t add attachments here, but absolutely no pressure.
      I am praying for you now.
      Jacqueline

      Reply

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